Can niacinamide replace nmn(Β-Nicotinamide Mononucleotide Powder)?

 1. What is the difference between nicotinamide mononucleotide and nicotinamide

Nicotinamide mononucleotide is what we often call NMN, and nicotinamide is a whitening ingredient, also known as NAM. 

Both of them have nicotinamide in their names, but they are two different substances. The main differences between NMN and niacinamide are:

1. Differences in ingredients

     Nicotinamide mononucleotide (NMN) is an organic compound with the chemical formula C11H15N2O8P that plays an important role in the production of energy in human cells. Nicotinamide is an amide compound of niacin with the chemical formula C6H6N2O.

2. Differences in security

     NMN  is a relatively safe ingredient. Normal use will not cause harm to the human body, and there may be some side effects of getting angry; nicotinamide is different. If it is used for a long time, it may reduce the activity of protease in the body, which may Cause liver damage, leading to liver toxicity.

3. Cost difference

     The manufacturing cost of NMN is very high, so its price is relatively high; the production of nicotinamide is very simple, and the cost is less than 100 yuan per kilogram, so some illegal traders will use nicotinamide to pretend to be nicotinamide mononucleotide.

2. Can nicotinamide replace nmn?

   As a health product, NMN mainly achieves anti-aging through NAD+. 

As a precursor of NAD+, due to its small molecular weight, NMN can be completely absorbed through the small intestine and increase the NAD+ content of the human body. 

Niacinamide is a member of the B vitamins. It can generate nmn under the catalysis of Nampt, so can nicotinamide replace NMN ?

The answer is no. Although nicotinamide can generate NMN and the cost is low, the intake of nicotinamide has a certain limit. 

If the intake is too much, side effects will occur. Common side effects include skin fever and hair loss. Redness, itching and stinging, long-term excessive intake can cause liver toxicity, so it is not advisable to obtain NAD+ by supplementing with niacinamide.

In addition, if nicotinamide wants to be converted into NMN and then into NAD+, it will be limited by the "rate-limiting enzyme", the conversion speed is slow, and the effect is greatly reduced, so nicotinamide cannot be used instead of NMN .